Ulingo lwezonyango luqalile eDemocratic Republic of the Congo (DRC) ukuhlola ukusebenza kwechiza le-antiviral tecovirimat (ekwaziwa njenge-TPOXX) kubantu abadala kunye nabantwana abane-monkeypox.Ulingo luza kuvavanya ukhuseleko lwechiza kunye nokukwazi kwalo ukunciphisa iimpawu zemonkeypox kunye nokuthintela iziphumo ezibi, kubandakanya ukufa.Ngaphantsi kobudlelwane be-PALM phakathi koorhulumente, i-National Institute of Allergy and Infectious Diseases (NIAID), inxalenye yeZiko leSizwe lezeMpilo, kunye neZiko leSizwe loPhando lwe-Biomedical (INRB) yaseDemocratic Republic of the Congo ikhokela isifundo..Ii-arhente ezisebenzisanayo ziquka i-US Centres for Disease Control and Prevention (CDC), i-Antwerp Institute of Tropical Medicine, i-International Alliance of Health Organizations (ALIMA), kunye ne-World Health Organization (WHO).
Iveliswe yinkampani yamachiza i-SIGA Technologies, Inc. (eNew York), i-TPOXX yi-FDA evunyiweyo kwi-smallpox.Ichiza linqanda ukusasazeka kwentsholongwane emzimbeni, lithintela ukukhutshwa kwamasuntswana entsholongwane kwiiseli zomzimba.Ichiza lijolise kwiprotheyini efumaneka kuzo zombini intsholongwane yengqakaqha kunye nentsholongwane yemonkeypox.
"I-Monkeypox ibangela umthwalo omkhulu wokugula nokufa phakathi kwabantwana kunye nabantu abadala kwi-Democratic Republic of the Congo, kunye neendlela eziphuculweyo zonyango zifuneka ngokukhawuleza," kusho uMlawuli we-NIAID u-Anthony S. Fauci, MD.Ukusebenza kwonyango lwemonkeypox.Ndingathanda ukubulela amaqabane ethu enzululwazi asuka e-DRC naseCongo ngentsebenziswano eqhubekayo ekuqhubeleni phambili olu phando lubalulekileyo lwezonyango.”
Intsholongwane yeMonkeypox ibangele iimeko ezingaqhelekanga kunye nokuqhambuka ukususela ngo-1970, ubukhulu becala kwimimandla yamahlathi emvula kuMbindi nakwiNtshona Afrika.Ukusukela ngoMeyi ka-2022, ukuqhambuka kwemonkeypox kumazwekazi amaninzi kuye kwaqhubeka kwiindawo apho esi sifo singekabikho, kubandakanya iYurophu kunye ne-United States, uninzi lwamatyala avela kumadoda abelana ngesondo namadoda.Uqhambuko lubangele uMbutho wezeMpilo weHlabathi kunye neSebe lezeMpilo lase-US kunye neeNkonzo zoLuntu ukuba zibhengeze imeko engxamisekileyo yezempilo yoluntu.Ukusukela nge-1 kaJanuwari 2022 ukuya ku-5 ka-Okthobha, i-WHO ibike amatyala angama-68,900 aqinisekisiweyo kunye nokufa kwabantu abangama-25 kumazwe angama-106, imimandla kunye nemimandla.
Ngokutsho koMbutho wezeMpilo weHlabathi, iimeko ezichongiweyo njengenxalenye yoqhambuko oluqhubekayo kwihlabathi zibangelwa ikakhulu yintsholongwane ye-Clade IIb monkeypox.UClade I uqikelelwa ukuba udala izifo ezimandla kunye nokufa okuphezulu, ngakumbi ebantwaneni, kune-clade IIa kunye ne-clade IIb, kwaye ingunobangela wosulelo eDemocratic Republic of the Congo.Ukususela ngoJanuwari 1, 2022 ukuya kuSeptemba 21, 2022, amaZiko e-Afrika oLawulo lweSifo kunye noThintelo (i-Afrika CDC) ibike iimeko ze-3,326 ze-monkeypox (i-165 iqinisekisiwe; i-3,161 irhanelwa) kunye nokufa kwe-120.
Abantu banokosulelwa yimonkeypox ngokudibana nezilwanyana ezosulelekileyo njengeempuku, iiprimates ezingengobantu, okanye abantu.Intsholongwane inokosulela phakathi kwabantu ngokudibana ngokuthe ngqo nezilonda zolusu, ulwelo lomzimba kunye namathontsi aphuma emoyeni, kubandakanywa ukunxibelelana ngokusondeleyo kunye nokwabelana ngesondo, kunye nokunxibelelana ngokuthe ngqo nempahla engcolisekileyo okanye ibhedi.I-monkeypox inokubangela iimpawu ezifana nomkhuhlane kunye nezilonda ezibuhlungu zolusu.Iingxaki zinokuquka ukuphelelwa ngamanzi emzimbeni, usulelo lwebhaktiriya, inyumoniya, ukudumba kobuchopho, isepsis, usulelo lwamehlo nokufa.
Ulingo luza kubandakanya ukuya kuthi ga kuma-450 abantu abadala kunye nabantwana abanosulelo lwemonkeypox oluqinisekiswe elebhu kunye nobunzima obuyi-3 kg.Abasetyhini abakhulelweyo nabo bafanelekile.Abathathi-nxaxheba bamavolontiya baya kubelwa ngokungenamkhethe ukuba bathathe i-tecovirimat okanye i-capsules ye-placebo ngomlomo kabini yonke imihla kwiintsuku ze-14 kwidosi exhomekeke kubunzima bomthathi-nxaxheba.Uphononongo lwaluyimfama kabini, ngoko ke abathathi-nxaxheba kunye nabaphandi babengazi ukuba ngubani oza kufumana i-tecovirimat okanye i-placebo.
Bonke abathathi-nxaxheba baya kuhlala esibhedlele ubuncinane iintsuku ezili-14 apho baya kufumana uncedo oluxhasayo.Oogqirha bomphandi baya kubeka iliso rhoqo imeko yeklinikhi yabathathi-nxaxheba kulo lonke uphando kwaye baya kucela abathathi-nxaxheba ukuba banike iisampulu zegazi, i-throat swabs, kunye nezilonda zesikhumba kuvavanyo lwebhubhoratri.Injongo ephambili yophononongo yayikukuthelekisa ixesha elithetha ukuphiliswa kwezilonda zesikhumba kwizigulane eziphathwe nge-tecovirimat ngokuchasene ne-placebo.Abaphandi baya kuqokelela idatha kwinani leenjongo zesibini, kubandakanywa ukuthelekisa ukuba abathathi-nxaxheba bavavanya ngokukhawuleza ukuba abanayo intsholongwane ye-monkeypox egazini labo, ubunzima obupheleleyo kunye nobude besifo, kunye nokufa phakathi kwamaqela.
Abathathi-nxaxheba bakhutshwe esibhedlele emva kokuba zonke izilonda zihlulwe okanye zihlulwe kwaye zavavanya zingenayo intsholongwane ye-monkeypox egazini labo iintsuku ezimbini ezilandelelanayo.Baza kujongwa kangangeentsuku ezingama-28 kwaye baya kucelwa ukuba babuye ngeentsuku ezingama-58 kutyelelo lophononongo olongezelelweyo lovavanyo olongezelelweyo lweklinikhi kunye nelebhu.Idatha ezimeleyo kunye nekomiti yokubeka iliso yokhuseleko iya kubeka iliso kukhuseleko lwabathathi-nxaxheba kulo lonke ixesha lokufunda.
Uphononongo lukhokelwa ngumphandi oyintloko uJean-Jacques Muyembe-Tamfum, uMlawuli Jikelele we-INRB kunye noProfesa weMicrobiology, i-Faculty of Medicine, iYunivesithi yaseKinshasa, eGombe, eKinshasa;Placid Mbala, MD, uMphathi weNkqubo yePALM, iNtloko yeCandelo le-INRB Epidemiology kunye nePathogen Genomics Laboratory.
“Ndiyavuya kuba inkawu ayisesosifo esingahoywanga kwaye kungekudala, ngenxa yolu phando, siza kukwazi ukubonisa ukuba lukhona unyango olusebenzayo kwesi sifo,” utshilo uGqirha Muyembe-Tamfum.
Ngolunye ulwazi, tyelela i-Clinicaltrials.gov kwaye ukhangele i-ID NCT05559099.Ishedyuli yovavanyo iya kuxhomekeka kwireyithi yobhaliso.Ulingo lwe-TPOXX oluxhaswa yi-NIAID luyaqhuba eMelika.Ngolwazi malunga nezilingo zase-US, tyelela i-website ye-AIDS Clinical Trials Group (ACTG) kwaye ukhangele i-TPOXX okanye ufunde i-A5418.
I-PALM sisishunqulelo se-"Pamoja Tulinde Maisha", ibinzana lesiSwahili elithetha "ukusindisa ubomi kunye".I-NIAID iseke intsebenziswano yophando lwezonyango lwePALM kunye noMphathiswa wezeMpilo we-DRC ekuphenduleni ukuqhambuka kwe-Ebola ka-2018 kwimpuma ye-DRC.Intsebenziswano iyaqhubeka njengenkqubo yophando lwezonyango yamazwe ngamazwe ebandakanya i-NIAID, iSebe lezeMpilo lase-DRC, i-INRB kunye namahlakani e-INRB.Uphononongo lokuqala lwe-PALM lulingo olulawulwa ngokungenamkhethe lwezonyango ezininzi ze-Ebola virus yesifo esixhasa ukuvunywa kwe-NIAID-developed mAb114 (Ebanga) kunye ne-REGN-EB3 (Inmazeb, ephuhliswe nguRegeneron).
I-NIAID iqhuba kwaye ixhasa uphando kwi-NIH, eUnited States, nakwihlabathi jikelele ukuqonda oonobangela bezifo ezosulelayo kunye ne-immune-mediated kunye nokuphuhlisa iindlela ezingcono zokuthintela, ukuxilonga nokunyanga ezi zifo.Ukukhutshwa kweendaba, iileta zeendaba, kunye nezinye izinto ezinxulumene ne-NIAID ziyafumaneka kwiwebhusayithi ye-NIAID.
Malunga namaZiko ezeMpilo eSizwe (i-NIH): IZiko leSizwe lezeMpilo (i-NIH) liziko lophando lwezonyango e-United States lamaziko e-27 kunye namaziko kwaye liyinxalenye yeSebe lezeMpilo lase-US kunye neeNkonzo zoLuntu.I-NIH yi-arhente ye-federal ephambili eyenza kwaye ixhase uphando lwezonyango olusisiseko, lweklinikhi, kunye nokuguqulela, ukuphanda izizathu, unyango, kunye nonyango lwezifo eziqhelekileyo kunye nezinqabileyo.Ngolwazi oluthe vetshe malunga ne-NIH kunye neenkqubo zayo, ndwendwela www.nih.gov.
Ixesha lokuposa: Oct-14-2022
